Studying epigenetic and epitranscriptomic mechanisms of drug resistance in malaria parasites

Small-Saunders, J.L., Sinha, A., Bloxham, T.S. et al. tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nat Microbiol (2024).

Hagenah LM, Dhingra SK, Small-Saunders JL, et al. Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology. mBio (2024).

Wicht KJ, Small-Saunders JL, Hagenah LM, et al. Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials. J Infect Dis. (2022).

Small-Saunders JL, Hagenah LM, Wicht KJ, et al. Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance. PLoS Pathog. (2022).